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KMID : 0603519980030020093
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Journal of Korean Association of Cancer Prevention
1998 Volume.3 No. 2 p.93 ~ p.100
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The Expression of p53 in Gastric Carcinoma
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Oho Won-Sup
Park Seun-Ja
Koo Ja-Young
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Abstract
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Background/Aims: This study was done to investigate the role of p53 in gastric carcinoma development and progression.
Method: The expression of p53 was studied by immunohistochemical staining applied to paraffin-embedded tissue sections of endoscopic biopsy materials of 71 cases of gastric carcinoma (24 early and 47 advanced), 22 intestinal metaplasia and 11 dysplasia.
Results: 1) p53 was expressed in 23 cases of total 71 gastric carcinoma (32.4%), and immunopositivity of p53 of the advanced carcinoma cases (34.0%) was not different from that of early carcinoma cases (29.2%). 2) The expression of p53 was not found in intestinal metaplasia, but 18.2% of dysplasia showed p53 immunopositivity. 3) The immunopositivity of p53 in well/moderately differentiated gastric carcinoma cases was 47.1% (16/34), and was significantly higher than 18.9% (7/37) of poorly differentiated group (p<0.05). 4) There was no correlation between the expression of p53 and the degree of mononuclear cell infiltration in tumor area, the elevation of serum CEA levels, the presence of distant metastses, and no difference was found in p53 expression according to metastses sites.
Conclusions: Above data suggest that abnormalities of p53 may play an important role in the late stage of carcinogenesis, especially in well/moderate differentiation group, permitting precancerous lesion to change to carcinoma, and immunohistochemical staining of p53 can be used in the early detection of gastric carcinoma.
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KEYWORD
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p53, Gastric carcinoma
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